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Hope in the battle against superbugs.
06-26-2014, 10:32 PM #1
UniqueStranger Art in my heart
Posts:15,061 Threads:428 Joined:Jun 2012
Quote:A team of researchers led by McMaster University in Hamilton, Ont., has discovered that a molecule derived from the fungus is able to disarm a gene found in many antibiotic-resistant “superbugs,” including E. coli.

The molecule is known as AMA and the gene it targets is called NDM-1 or New Delhi Metallo-beta-Lactamase-1.


Read more: http://www.ctvnews.ca/health/nova-scotia...z35m8GtPb4

Video at link.

I think they need to push this forward double time.
06-26-2014, 10:41 PM #2
Octo Mother Superior
Posts:43,001 Threads:1,473 Joined:Feb 2011
That's very good news! But 10 years is an awful long time damned.gif
06-26-2014, 10:50 PM #3
UniqueStranger Art in my heart
Posts:15,061 Threads:428 Joined:Jun 2012
I wonder if it was this specific fungi...because if it is of the same family, then there is past research to fall back on to speed up research.

http://www.ncbi.nlm.nih.gov/pubmed/1577658
06-27-2014, 01:03 AM #4
Octo Mother Superior
Posts:43,001 Threads:1,473 Joined:Feb 2011
I have no clue, but obviously research has been done.

Seems odd though that tests on mice have been done and human trials would be as far as 10 years away... Did they mean it would take that long to synthesize it and patent it so they can sell it? hmm.gif
06-27-2014, 02:06 AM #5
JayRodney ⓐⓛⓘⓔⓝ
Posts:31,393 Threads:1,439 Joined:Feb 2011
At the 1:09 mark in the video:

"A lot of the antibiotics and drugs, uh...as a whole, that we use are uh... from dirt... people just don't necessarily realize that"

damned.gif I didn't know that. Interesting find US.

wonder.gif
Anonymous Kritter Show this Post
06-27-2014, 02:17 AM #6
Anonymous Kritter Incognito Anonymous
 
(06-27-2014, 01:03 AM)Octo Wrote:  I have no clue, but obviously research has been done.

Seems odd though that tests on mice have been done and human trials would be as far as 10 years away... Did they mean it would take that long to synthesize it and patent it so they can sell it? hmm.gif

Big pharm stopped creating new antibiotics long ago so they need to create a demand so they can charge a arm and leg that what will need to be cut off if you don't
lmao.gif
06-27-2014, 02:25 AM #7
UniqueStranger Art in my heart
Posts:15,061 Threads:428 Joined:Jun 2012
(06-27-2014, 01:03 AM)Octo Wrote:  I have no clue, but obviously research has been done.

Seems odd though that tests on mice have been done and human trials would be as far as 10 years away... Did they mean it would take that long to synthesize it and patent it so they can sell it? hmm.gif

Yes, that seems to be what was said in the video, that perhaps the University should start their own side pharm business. blink.gif
06-27-2014, 03:27 PM #8
UniqueStranger Art in my heart
Posts:15,061 Threads:428 Joined:Jun 2012
Quote:'Valley of death' trial phase ahead

All of that means it will be up to Wright to push this development through what is known in the drug development business as "the valley of death," the bleak early trial phase where promising lab discoveries often falter and die.

To preserve the value of the discovery, the first thing the researchers did was take out a patent, in the name of McMaster University. Wright said that without patent protection, future investors would not be able to recover their investment, which would be substantial. It costs millions of dollars to put new molecules through all of the clinical trials that are required to convince regulators that a compound is safe and it works.

The next step is to take advantage of U.S. government funding to complete the toxicology and pharmacological studies. The U.S. National Institutes of Health has accepted Wright’s molecule into a special program that will cover the cost of some initial studies and help prepare the discovery for private investment.

"If we can get these studies done, then they’ll be more interested," he said. "If not, then we’ll just start our own drug company."

Despite the discovery’s potential, Wright is realistic. "It could fail in a microsecond. It could have some side-effects that we don’t want and that could ruin it all. But so far it looks pretty good."

http://www.cbc.ca/news/health/antibiotic...-1.2686347

Thank you Gerry Wright, McMaster University and the U.S. gov't for trying. cheers.gif



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