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I'll drink to that: Switch Causes Mature Liver Cells to Revert Back to Stem Cell-Like State
06-07-2014, 05:33 PM #1
JayRodney ⓐⓛⓘⓔⓝ
Posts:31,396 Threads:1,439 Joined:Feb 2011
Scientists have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state. The researchers happened upon this discovery while investigating whether a biochemical cascade called Hippo, which controls how big the liver grows, also affects cell fate. The unexpected answer is that switching off the Hippo-signaling pathway in mature liver cells generates very high rates of dedifferentiation. This means the cells turn back the clock to become stem-cell like again, thus allowing them to give rise to functional progenitor cells that can regenerate a diseased liver.

Read more: sciencedaily.com

Very interesting, may give hope to a lot of people with liver problems, and give alcoholics a longer time in which to enjoy the beverage of their choice. coffeetime.gif

wonder.gif
06-07-2014, 05:36 PM #2
Octo Mother Superior
Posts:43,018 Threads:1,474 Joined:Feb 2011
How do I intercept my Hippo signal? hyper.gif



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