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Researchers Inadvertently Turn Off Skin Aging Gene!
12-17-2014, 04:31 PM #1
JayRodney ⓐⓛⓘⓔⓝ
Posts:30,310 Threads:1,477 Joined:Feb 2011
Scientists at the University of B.C. searching for ways to slow the deterioration of blood vessels may have stumbled on to the key to youthful skin.

While exploring the effects of the protein-degrading enzyme Granzyme B on blood vessels during heart attacks, professor David Granville couldn’t help noticing that mice engineered to lack the enzyme had beautiful skin at the end of the experiment, while normal mice showed signs of age.[...]

“We were interested in the effects of aging on blood vessels; we had no idea (the absence of this enzyme) would have any effect on their skin.”

The discovery pushed Granville’s research in an unexpected new direction.

The researchers built a mechanized rodent tanning salon and exposed mice engineered to lack the enzyme and normal mice to UV light three times a week for 20 weeks, enough to cause redness, but not to burn.

At the end of the experiment, the engineered mice still had smooth, unblemished skin, while the normal mice were deeply wrinkled.

“About 80 to 90 per cent of visible skin aging is caused by sunlight,” said Granville. “We found that by knocking out this gene we could markedly protect against the loss of collagen and it prevented wrinkling in these mice.” [...]

Read more: theprovince.com

One can't help think this enzyme exists for a reason.
I mean, yes it's great to be 60 with the skin of a 20 year old, but does it come with increased cancer risk?
Or turn the entire population into the equivalent of vampires staying out of the sun?
The other question... what about systemic effects? Is this slowing down the entire aging process? Is it slowing down the skins aging while speeding up internal aging?
So many questions, but I found this quite interesting.

12-17-2014, 04:56 PM #2
Octo Mother Superior
Posts:40,976 Threads:1,526 Joined:Feb 2011
Quote:The researchers built a mechanized rodent tanning salon

And this is not part of the Canadian rodent bra research?
12-17-2014, 05:52 PM #3
yankees skier
Posts:5,093 Threads:215 Joined:Feb 2011

Anonymous Kritter Show this Post
12-17-2014, 06:14 PM #4
Anonymous Kritter Incognito Anonymous
her face looks no different from when she was a lion cub.
12-17-2014, 06:18 PM #5
JayRodney ⓐⓛⓘⓔⓝ
Posts:30,310 Threads:1,477 Joined:Feb 2011

12-18-2014, 01:37 AM #6
Accidental Stoner Member
Posts:8,714 Threads:78 Joined:Feb 2011
(12-17-2014, 05:52 PM)yankees Wrote:  İmage

Dammit, yankees.

You could've warned us.

12-18-2014, 01:47 AM #7
Accidental Stoner Member
Posts:8,714 Threads:78 Joined:Feb 2011
Granzyme, Granville...they seem related.


Ain't that gran.

Granzyme B: a natural born killer

Interesting...not that I get the specifics of it, but the geist seems clear:

Quote:A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate pathogenic cells is via exocytosis of granule components in the direction of the target cell, delivering a lethal hit of cytolytic molecules. Amongst these, granzyme B and perforin have been shown to induce CTL-mediated target cell DNA fragmentation and apoptosis.




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