People who’ve suffered childhood abuse are particularly vulnerable – but having one particular genetic variation seemed to protect against dependence.
Researchers from Washington University in St. Louis focused on 1,558 Australian survivors of childhood trauma – in particular sexual abuse.
Even among survivors of abuse, not all went on to become dependent. But those who did had one particular variation within the body’s endocannabinoid system – the system which cannabis affects.
‘We have long known that childhood adversity, and in particular sexual abuse, is associated with the development of cannabis dependence. However, we understand very little about the individual difference factors that leave individuals vulnerable or resilient to these effects,’ says Ryan Bogdan of Washington